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Olorukooba et al

 

ANTI-PYRETIC AND ANTI-INFLAMMATORY STUDIES ON THE ETHYL ACETATE FRACTION OF UAPACA TOGOENSIS (PAX) STEM BARK IN RATS

 

Olorukooba, A. B., Maiha, B. B., Chindo, B. A., Ejiofor, J. I. and Shehu, A.

 

Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria This email address is being protected from spambots. You need JavaScript enabled to view it.

 

 

Medicinal plants have been used in traditional medicine for the treatment of various ailments including pain, epilepsy, rheumatism, female infertility, fatigue and vomiting. The plant Uapaca togoensis belonging to the family Euphorbiaceae, is an evergreen tree found mainly in the rainforest zones of West and Central Africa, with the stem bark and leaves mostly used as medicines.  This study was designed to investigate the anti-pyretic and anti-inflammatory effects of the ethyl acetate fraction of Uapaca togoensis stem bark in rats.

Phytochemical screening was conducted using standard protocol followed by acute toxicity studies. Anti-pyretic and anti-inflammatory effects of the fraction (250, 500, 1000 mg/kg, orally) were evaluated using Brewer’s yeast-induced pyrexia and carrageenan-induced paw oedema, respectively, in rats. Results were analysed using repeated measures ANOVA followed by Bonferroni post-hoc tests. Phytochemical screening revealed the presence of glycosides, carbohydrates, alkaloids, tannins, saponins and flavonoids. The oral LD50 in rats was found to be greater than 5000mg/kg indicating the relative safety of the fraction. The fraction showed significant (p<0.05) reduction of paw oedema at the doses of 250, 500 and 1,000 mg/kg producing 37.50%, 36.54% and 40.38% inhibition, respectively at the 5th hour. However, there was no statistically significant reduction in rectal temperature at all tested doses. The findings from this study showed that the ethyl acetate fraction of Uapaca togoensis stem bark possesses anti-inflammatory activity with no anti-pyretic effect.